Classic Holby City

Name: Hope Is a Powerful Drug
Duration: 1 h 15 min

S21 E42 ∙ Hope Is a Powerful Drug ∙ 75 min

Frankie returns to Holby, keen to take Isla back. Essie is not convinced she is truly ready for the demands of parenthood.

Contains Mature Themes

S21 E1 · Everything Old Is New Again
While on a road trip, Jac, Ric and Sacha confront some old enemies.
S21 E2 · China Crisis
A face from the past continues to wreak havoc when he returns to the hospital.
S21 E3 · The Burden of Proof
Cameron clashes with Jac.
S21 E4 · A Daring Adventure or Nothing at All
Frieda's contentment is shattered when Roman reappears.
S21 E5 · Mad as Hell
Ric goes above and beyond to treat his patients.
S21 E6 · Force Majeure
When a family secret is exposed, the dispute causes a patient to delay surgery.
S21 E7 · Good Side
Holly's parents must make a heart-breaking decision.
S21 E8 · Never Say Never
A frustrated Jac tries to track down Frieda.
S21 E9 · Guts
Sacha is rattled when an old flame appears.
S21 E10 · Powerless
The hospital's power shuts down.
S21 E11 · A Simple Lie, Part One
The high court gives its judgement on withdrawing care for Ange's patient.
S21 E12 · A Simple Lie, Part Two
Fletch worries there may be more to Theo's disappearance than meets the eye.
S21 E13 · Running
Ange uncovers a long-buried secret.
S21 E14 · Ask No Questions
Chloe is wrong-footed when ex-boyfriend Evan turns up on Darwin.
S21 E15 · The Family Way
Dom throws himself into work as he struggles to process a family secret.
S21 E16 · North & South
A startling incident forces Zosia to reconsider her future at Holby.
S21 E17 · Pleased to Meet You
Jac's status is challenged when a new surgeon starts at the hospital.
S21 E18 · Vinegar & Honey
Kian's personality and alternative methods begin to grate on Jac.
S21 E19 · Ex Marks the Spot
Ange plans to tell Chloe her biggest secret.
S21 E20 · The Wrong Horse
Lofty returns to the hospital with a secret.
S21 E21 · Unredeemed
Dominic tries to give Isaac's father the best treatment possible.
S21 E22 · Bloodline
As Dominic continues to treat Isaac's father, Lofty is determined to protect him.
S21 E23 · In the Right Place
Dom makes a risky decision which lands him in hot water.
S21 E24 · Over My Dead Body
Isaac puts Lofty in harm's way to drive a wedge between him and Dom.
S21 E25 · Pigeon
Xavier's mum arrives on AAU, talking in riddles.
S21 E26 · Kiss Kiss
Xavier tries to build bridges with Donna.
S21 E27 · Flying Solo
Cameron tries to prove himself to Kian.
S21 E28 · Reckless
Chloe's day is thrown into chaos when Evan is attacked.
S21 E29 · Honeymoon
As loved ones continue to worry about her, Chloe starts to learn more about Evan.
S21 E30 · Don't Leave Me
Kian vows to save a life on the anniversary of a personal tragedy.
S21 E31 · Things My Mother Told Me
The team gives a warm send-off to a beloved colleague.
S21 E32 · When Worlds Collide
Jac is forced to make a career-changing decision when she is reunited with her daughter.
S21 E33 · Work-Life Balance
Chloe desperately tries to convince Evan that their marriage is over.
S21 E34 · Where Does It Hurt?
Essie makes a pact with a stranger that could change her life for ever.
S21 E35 · Babysitters & Bystanders
Chloe is dismayed as Evan works his way back into her life.
S21 E36 · The Perfect Storm
Jac is confronted with the return of old rival Faye.
S21 E37 · Gods & Monsters
As Ric celebrates his birthday, he realises he is losing his surgical skills.
S21 E38 · Circle of Life
Ric fears for his health as his granddaughter goes into premature labour.
S21 E39 · Retreat
Evan's obsession with Chloe turns violent.
S21 E40 · Divine Justice
Chloe is interviewed over her assault, while Ange battles to keep Evan alive.
S21 E41 · This Be the Verse
Ric tries to keep his diagnosis from Darla, who faces a tough choice of her own.
S21 E42 · Hope Is a Powerful Drug
Frankie returns to Holby and is keen to take Isla back.
S21 E43 · Promise
Ric undergoes dangerous brain surgery.
S21 E44 · Hubble Bubble
Cameron makes a fatal mistake on Halloween.
S21 E45 · Remember, Remember
Jac performs a milestone operation in the 1000th episode.
S21 E46 · Sandra's Choice
A paranoid Jac feels she is the centre of hospital gossip.
S21 E47 · We Are All the Stars
Helen bravely admits her true feelings.
S21 E48 · Blurring the Lines
Kian is desperate to deliver the surgery that Bea desires, but Jac refuses to help.
S21 E49 · Bell Jar
Elliot needs life-changing surgery that only Jac can perform.
S21 E50 · Kintsugi
Jac is confined to a psychiatric unit, and refuses to accept that she has a problem.
S21 E51 · Lemons
Lofty and Dom prepare to renew their wedding vows.
S21 E52 · Be True, Be Brave, Be Kind
Kian performs emergency surgery - despite having been suspended.
S21 E53 · Mothers & Their Daughters
Serena is forced to make a life or death decision.